Drug modifies epigenome in aggressive brain tumors

Journal Reference: Lucas A. Salas, Thomas G. Stewart, Bret C. Mobley, Chengwei Peng, Jing Liu, Sudan N. Loganathan, Jialiang Wang, Yanjun Ma, Mitchel S. Berger, Devin Absher, Yang Hu, Paul L. Moots, Brock C. Christensen, Stephen W. Clark. Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade … Read more

Engineered nanomaterial captures off-target cancer drug to prevent tissue damage

Journal Reference: Sarah A.E. Young, Joy Muthami, Mica Pitcher, Petar Antovski, Patricia Wamea, Robert Denis Murphy, Reihaneh Haghniaz, Andrew Schmidt, Samuel Clark, Ali Khademhosseini, Amir Sheikhi. Engineering hairy cellulose nanocrystals for chemotherapy drug capture. Materials Today Chemistry, 2022; 23: 100711 DOI: 10.1016/j.mtchem.2021.100711 “To reduce the off-target effects of cancer drugs during and after localized chemotherapy, … Read more

‘Unexciting’ an anxious mind: Novel drug reduces anxiety-like behavior in mice

Journal Reference: Daisuke Yamada, Junpei Takahashi, Keita Iio, Hiroshi Nagase, Akiyoshi Saitoh. Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice. Biochemical and Biophysical Research Communications, 2021; 560: 192 DOI: 10.1016/j.bbrc.2021.05.002 For a group of Japanese researchers from Tokyo University of Science and University of … Read more

Addiction relapse driven by drug-seeking behavior, not just drug

Journal Reference: Maxime Fouyssac, Yolanda Peña-Oliver, Mickaёl Puaud, Nicole T.Y. Lim, Chiara Giuliano, Barry J. Everitt, David Belin. Negative Urgency Exacerbates Relapse to Cocaine Seeking After Abstinence. Biological Psychiatry, 2021; DOI: 10.1016/j.biopsych.2021.10.009 The study appears in Biological Psychiatry, published by Elsevier. Given the importance of the drug itself in the development and perpetuation of SUD, … Read more

Drink and drug risk is lower among optimistic pupils with ‘completely satisfied’ memories

Drink and drug risk is lower among optimistic pupils with ‘completely satisfied’ memories – NovLink Home Mash G Drink and drug risk is lower among optimistic pupils with ‘completely satisfied’ memories We would like to say thanks to the author of this write-up for this incredible material Drink and drug risk is lower among optimistic … Read more

Now scientists can efficiently screen billions of chemical compounds to find effective new drug therapies

Journal Reference: Arman A. Sadybekov, Anastasiia V. Sadybekov, Yongfeng Liu, Christos Iliopoulos-Tsoutsouvas, Xi-Ping Huang, Julie Pickett, Blake Houser, Nilkanth Patel, Ngan K. Tran, Fei Tong, Nikolai Zvonok, Manish K. Jain, Olena Savych, Dmytro S. Radchenko, Spyros P. Nikas, Nicos A. Petasis, Yurii S. Moroz, Bryan L. Roth, Alexandros Makriyannis, Vsevolod Katritch. Synthon-based ligand discovery in … Read more

No more barrels, heavily toxic drug waste goes straight into the ground – Liberal policy, empty stables and agility at sea attractive to drug criminals – Foodlog

No more barrels heavily toxic drug waste goes straight into

The drug industry is becoming more and more intertwined with agriculture and nature. A recently published video triptych van Algemeen Dagblad outlines the latest developments. Previously we saw an increase in the number of barrels of drug waste being dumped in the forests, nowadays criminals just as easily lay a drain hose from the drug … Read more

Repurposed ALS drug shows promise in mouse model of rare childhood genetic disorder

Journal Reference: Antony Cougnoux, Julia C. Yerger, Mason Fellmeth, Jenny Serra-Vinardell, Fatemeh Navid, Christopher A. Wassif, Niamh X. Cawley, Forbes D. Porter. Reduction of glutamate neurotoxicity: A novel therapeutic approach for Niemann-Pick disease, type C1. Molecular Genetics and Metabolism, 2021; DOI: 10.1016/j.ymgme.2021.11.008 The study was conducted by Forbes D. Porter, M.D., Ph.D., of NIH’s Eunice … Read more

Common blood pressure drug does not slow down the progression of more advanced Alzheimer’s, study finds

Common blood pressure drug does not slow down the progression of more advanced Alzheimer’s, study finds – NovLink Home Mash I Common blood pressure drug does not slow down the progression of more advanced Alzheimer’s, study finds We want to give thanks to the writer of this post for this awesome content Common blood pressure … Read more

CRISPR screen identifies new anti-inflammatory drug target

Journal Reference: Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, Katherine L. Beier, Nowrin U. Chowdhury, Melissa M. Wolf, Arissa C. Young, Dalton L. Greenwood, Allison E. Sewell, Shailesh K. Shahi, Samantha N. Freedman, Alanna M. Cameron, Patrik Foerch, Tim Bourne, Juan C. Garcia-Canaveras, John Karijolich, Dawn … Read more

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