Drug modifies epigenome in aggressive brain tumors

Journal Reference: Lucas A. Salas, Thomas G. Stewart, Bret C. Mobley, Chengwei Peng, Jing Liu, Sudan N. Loganathan, Jialiang Wang, Yanjun Ma, Mitchel S. Berger, Devin Absher, Yang Hu, Paul L. Moots, Brock C. Christensen, Stephen W. Clark. Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade … Read more

Research breakthrough could see HIV drugs used to treat low-grade brain tumors

Journal Reference: Emmanuel A Maze, Bora Agit, Shona Reeves, David A Hilton, David B. Parkinson, Liyam Laraba, Emanuela Ercolano, Kathreena M Kurian, C. Oliver Hanemann, Robert D Belshaw, Sylwia Ammoun. Human endogenous retrovirus type K promotes proliferation and confers sensitivity to anti-retroviral drugs in Merlin-negative schwannoma and meningioma.. Cancer Research, 2021; canres.3857.2020 DOI: 10.1158/0008-5472.CAN-20-3857 The … Read more

Asthma may reduce risk of brain tumors — but how?

Journal Reference: Jit Chatterjee, Shilpa Sanapala, Olivia Cobb, Alice Bewley, Andrea K. Goldstein, Elizabeth Cordell, Xia Ge, Joel R. Garbow, Michael J. Holtzman, David H. Gutmann. Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27455-6 It comes down to the behavior of T cells, a type … Read more

Using T cells to target malignant brain tumors

Journal Reference: Michael Kilian, Mirco Friedrich, Khwab Sanghvi, Edward Green, Stefan Pusch, Daisuke Kawauchi, Martin Löwer, Jana K. Sonner, Christopher Krämer, Julia Zaman, Stefanie Jung, Michael O. Breckwoldt, Gerald Willimksy, Stefan B. Eichmüller, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten, Lukas Bunse. T cell receptor therapy targeting mutant capicua transcriptional repressor in experimental … Read more

How diet affects tumors

Journal Reference: Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin, Matthew G. Vander Heiden. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature, 2021; DOI: 10.1038/s41586-021-04049-2 The study examined the effects of a calorically restricted diet and a ketogenic diet … Read more

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